Inherited Cancers: Susceptibility And Features

smokingAll cancers are caused by alteration or mutation of genes and in so far as that is concerned all cancers are genetic.

However all cancers are not genetic in that it is inherited; cancer is caused by inherited predisposition only in 5 to 10% according to some experts.

Further there are some kinds of cancer that owe themselves more or less to inheritance according to their types.

For instance lung cancer owes itself more to environmental risk factors such as smoking, dietary habits or exposure to certain pollutants while cancers of the breast tend to owe themselves to genetic or inherited susceptibility as well.

The range of cancers, the age at onset, and the number of generations affected all suggest familial risk being a factor in the incidence of developing cancer.

Further different types of cancer occurring within one family can also indicate some inherited predisposition as in the case of breast and ovarian cancer, breast and sarcoma, colorectal, uterine ovarian and stomach cancers.

Having a close relative who has cancer does increase a person’s risk of cancer and there are ways to identify if the member of certain families have a predisposition to or risk from cancer, which are sometimes known as ‘red flags’:

  • The autosomal dominant pattern of inheritance which has several members of a family suffering from cancer and that pattern is repeated or observed over several generations.
  • When cancer strikes early. Early onset is usually defined as cancer that is contracted by a person below 50 years of age.
  • When a person displays cancer clusters as multiple cancers such as cancers of the breast and the ovary, of the colon and the uterus etc.
  • Multiple cancers other than cancer clusters or a cancer that starts from one organ or site and then extends to other organs or part of the body. Here there is more than one cancer but they take place as separate occurrences that do not have a common origin. These are known as multiple primary cancers.
  • The incidence of rare cancers such as male breast cancer etc

Experts suggest that families that have such genetic predisposition towards developing cancer could benefit from counseling from a geneticist or counselor so that this predisposition in terms of the family’s history can be better understood.


Posted in: Cancer Info

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  1. cancer types says:

    There are several types of genes which can cause inherited susceptibility to cancer if inherited in a faulty state. Certain common types of cancer show a tendency to affect some families in a disproportionately high degree. If two or more close relatives of a patient with cancer have the same type of tumour, an inherited susceptibility should be suspected. Other features of these syndromes are early age of onset of the tumours and multiple tumours in the same organ or tissue.