A study suggests that selenium, a trace mineral found in grains, nuts and meats, may aid in the prevention of high-risk bladder cancer.
Researchers from Dartmouth Medical School compared selenium levels in 767 individuals newly diagnosed with bladder cancer to the levels of 1,108 individuals from the general population.
Findings showed an inverse association between selenium and bladder cancer among women, some smokers and those with p53 positive bladder cancer.
In the entire study population, there was no inverse association between selenium and bladder cancer, but women (34 percent), moderate smokers (39 percent) and those with p53 positive cancer (43 percent) had significant reductions in bladder cancer with higher rates of selenium.
“There are different pathways by which bladder cancer evolves and it is thought that one of the major pathways involves alterations in the p53 gene,” said corresponding author Margaret Karagas, Ph.D., professor of community and family medicine of the Norris Cotton Cancer Center at Dartmouth. “Bladder cancers stemming from these alternations are associated with more advanced disease.”
While other studies have shown a similar association between selenium and bladder cancer among women, this study is one of the first to show an association between selenium and p53 positive bladder cancer.
Read more at Medical News Today
